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SALL4 peptide FFW
CAS No.
SALL4 peptide FFW ( RRKFAKFQWI;FFW peptide )
Catalog No. M17053 CAS No.
SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSALL4 peptide FFW
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NoteResearch use only, not for human use.
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Brief DescriptionSALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD.
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DescriptionSALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD (nucleosome remodeling deacetylase) interaction with target affinity of 23 nM; reverses Transcription Repression by SALL4-RBBp4, disrupts the SALL4-NuRD complex resulted in unidirectional up-regulation of transcripts, turning SALL4 from a dual transcription repressor-activator mode to singular transcription activator mode; displays significant antitumor effects, inhibiting tumor growth by 85% in xenograft mouse models of HCC.
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SynonymsRRKFAKFQWI;FFW peptide
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight1378.70
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Molecular FormulaC67H103N21O11
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameArg-Arg-Lys-Phe-Ala-Lys-Phe-Gln-Trp-Ile-NH2
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu BH, et al. Proc Natl Acad Sci U S A. 2018 Jul 5. pii: 201801253.
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