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SALL4 peptide FFW

CAS No. ——

SALL4 peptide FFW( RRKFAKFQWI | FFW peptide )

Catalog No. M17053 CAS No. ——

SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SALL4 peptide FFW
  • Note
    Research use only, not for human use.
  • Brief Description
    SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD.
  • Description
    SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD (nucleosome remodeling deacetylase) interaction with target affinity of 23 nM; reverses Transcription Repression by SALL4-RBBp4, disrupts the SALL4-NuRD complex resulted in unidirectional up-regulation of transcripts, turning SALL4 from a dual transcription repressor-activator mode to singular transcription activator mode; displays significant antitumor effects, inhibiting tumor growth by 85% in xenograft mouse models of HCC.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RRKFAKFQWI | FFW peptide
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    1378.697
  • Molecular Formula
    C67H103N21O11
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Arg-Arg-Lys-Phe-Ala-Lys-Phe-Gln-Trp-Ile-NH2

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu BH, et al. Proc Natl Acad Sci U S A. 2018 Jul 5. pii: 201801253.
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